The present study aims to explore the neuroprotective role of methanol extract of Cordia dichotoma (MCD) in the cerebral ischemia-reperfusion induced injury in mice. Swiss Albino mice (either sex), weighing between 18-30 g were used in this study. Animals were divided in 6 groups (n= 6-8). Bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in mice. Short-term memory was evaluated using the elevated plus maze test and rotarod apparatus was used to assess motor incoordination. MCD was administered in 3 doses (125, 250 and 500 mg/kg; p.o.) to mice for 7 successive days daily before surgery. Edaravone (3 mg/kg, i.p.) was used as standard drug. Animals were sacrificed after all behavioral parameters and 24 hr after surgery for biochemical estimations (TBARS, GSH, SOD, catalase and total brain protein estimations). Ischemia-Reperfusion-injury induces decrease in motor-co-ordination and memory of mice. Further ischemic mice showed higher brain TBARS and lowered GSH, SOD and catalase levels. MCD (500 mg/kg/p.o.) administration significantly attenuated (p<0.05) the behavioral and biochemical alterations produced by ischemia-reperfusion-Injury. Thus, MCD may prove to be useful remedy for the management of cerebral ischemia owing to its potent antioxidant properties.
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